tag:blogger.com,1999:blog-1078685116296921818.post265796517450628342..comments2023-04-26T09:15:19.142-04:00Comments on CFS Central: DUSTY MILLER'S XMRV STUDYMindy Kiteihttp://www.blogger.com/profile/12570126270241201680noreply@blogger.comBlogger69125tag:blogger.com,1999:blog-1078685116296921818.post-50262976252835624132011-07-02T10:11:37.361-04:002011-07-02T10:11:37.361-04:00The new isolate is XMRV and from Lithuania.
It i...The new isolate is XMRV and from Lithuania. <br /><br />It is not from the US, so why would anyone believe it should be as close to VP62 as the WPI sequences? Also, people will, like mice, have other strains and variants within them. <br /><br />The new CDC sequences also fall between this new isolate and the ones that were previously in the GenBank.<br /><br />Where do you get the idea that Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-30968222137955603922011-06-29T02:12:35.798-04:002011-06-29T02:12:35.798-04:00It's really very simple: if true (i.e. if this...It's really very simple: if true (i.e. if this new sequence is indeed a strain of XMRV) then you would have several full isolates from the WPI that are ~99% identical to a lab clone (and each other), even more partial sequences from WPI that are also very similar (98-100%) to this lab clone (and each other) and one (1) isolate from another lab that suddenly shows ~5 times more diversity than RRMnoreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-10381698007318919612011-06-27T14:43:23.818-04:002011-06-27T14:43:23.818-04:00The new isolate in the GenBank is 95% similar to t...The new isolate in the GenBank is 95% similar to the VP62 strain of XMRV. It meets the requirements to be called XMRV.<br /><br />You don't say why you believe that XMRV is not like HTLV, but the man who discovered HTLV, Frank Ruscetti, disagrees with you. He says it is not contamination.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-12234694787251615802011-06-23T00:35:30.700-04:002011-06-23T00:35:30.700-04:00Wrong try again.Wrong try again.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-64228607818355519822011-06-22T17:14:09.567-04:002011-06-22T17:14:09.567-04:00Yes, it does. If true, it definitely shows that an...Yes, it does. If true, it definitely shows that any study which shows absolutely no significant variation in sequences collected around the globe (like Lombardi et al.) is contamination. The HTLV-1 hypothesis doesn't fly.<br /><br />Think people. Think.RRMnoreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-19390311687442015862011-06-21T23:06:34.423-04:002011-06-21T23:06:34.423-04:00Well this should take away the doubt.
http://www...Well this should take away the doubt. <br /><br />http://www.ncbi.nlm.nih.gov/nuccore/FR872816.1<br /><br />XMRV complete proviral genome, isolate S-162<br />GenBank: FR872816.1<br /><br />AUTHORS - Sabaliauskaite,R., Bulavaite,A. and Lazutka,J.R.<br /><br />TITLE - Xenotropic murine leukemia virus-related viruses in Lithuanian prostate cancer patient population<br /><br />JOURNAL - Unpublished<Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-18945834778867516572011-06-19T09:12:29.802-04:002011-06-19T09:12:29.802-04:00According to Miller we don't know if 22Rv1 cel...According to Miller we don't know if 22Rv1 cell line is infected with XMRV, as only 30% has been sequenced and assumed to be XMRV. Miller is therefore relying on his opinion and not evidence. <br /><br />If we only ever use our experience and stick rigidly to the same mould when presented with new data, then progress will never be made. Flat earthers' spring to mind. <br /><br />Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-4465554153569058162011-06-19T08:31:50.766-04:002011-06-19T08:31:50.766-04:00No, it stinks of another shoddy, quick and dirty s...No, it stinks of another shoddy, quick and dirty study meant solely to kick out more "proof" that this third retrovirus does not exist. <br />Look under the rocks and bullshit_t to find the strong and controlling hands of the US and UK governments. The "whomevers" within both governments are terrified and working over time to kill this retrovirus off and all further research.sharonnoreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-26293685145756875832011-06-18T13:50:41.140-04:002011-06-18T13:50:41.140-04:00Dr. Miller, what proof do you have that PreXMRV-1 ...Dr. Miller, what proof do you have that PreXMRV-1 exists?<br /><br />Quote: PreXMRV-1 was found using primers that are also capable of detecting XMRV. Therefore they have no reason to claim the existance of PreXMRV-1. What they threw together has only been labelled PreXMRV-1, but may infact be XMRV sequences + other seqeuences from other viruse.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-8417500841915770062011-06-17T18:52:59.429-04:002011-06-17T18:52:59.429-04:00PreXMRV-1 was found using primers that are also ca...PreXMRV-1 was found using primers that are also capable of detecting XMRV. Therefore they have no reason to claim the existance of PreXMRV-1. What they threw together has only been labelled PreXMRV-1, but may infact be XMRV sequences + other seqeuences from other viruses.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-77111981448978652142011-06-17T18:38:44.541-04:002011-06-17T18:38:44.541-04:00Dear Anonymous,
You tiresome idiot, PreXMRV-1 is ...Dear Anonymous,<br /><br />You tiresome idiot, PreXMRV-1 is an endogenous retrovirus found in nude mice. The complete sequence of PreXMRV-1 is available from GenBank, accession number FR871849.1. Read the recent Science paper from Paprotka et al. to see how it recombines to form XMRV.Dusty Millernoreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-87383322464668987472011-06-17T18:10:36.790-04:002011-06-17T18:10:36.790-04:00He won't answer that after avoiding the issue ...He won't answer that after avoiding the issue in his post up until now.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-16630890564695662092011-06-17T16:29:50.814-04:002011-06-17T16:29:50.814-04:00Dusty, exactly what is PreXMRV-1? Where does it c...Dusty, exactly what is PreXMRV-1? Where does it come from? How does it combine to form XMRV?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-75071954123826832072011-06-17T16:16:38.106-04:002011-06-17T16:16:38.106-04:00You have nothing to say about the details do you D...You have nothing to say about the details do you Dusty. Can't argue the details can you.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-25676178194190916722011-06-17T16:04:34.926-04:002011-06-17T16:04:34.926-04:00Hey you, Anonymous, arbiter of the Scientific Meth...Hey you, Anonymous, arbiter of the Scientific Method! Come out from behind that tree so I can see your credentials. What, don't want to show yourself?<br /><br />Do you list yourself as Anonymous on your scientific papers? I'd like to look up your work.Dusty Millernoreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-37700696981211640962011-06-17T15:18:47.878-04:002011-06-17T15:18:47.878-04:00Dusty, congratulations in becoming another of thos...Dusty, congratulations in becoming another of those contamination fanatics. All you can do is cling to your immaculate contamination like religious zealots, but refuse to put any data to the test. That is not science.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-55841606727917648162011-06-17T15:05:17.788-04:002011-06-17T15:05:17.788-04:00Dusty, try and stick to the scientific method. Th...Dusty, try and stick to the scientific method. The serology results can only be to an MLV virus. Humans have not been shown to be resistant to MLVs and no other hypothesis for another virus as the cause of ME/CFS exists. This data from Lombardi et al. has never been challenged.<br /><br />I have seen all the data from all the published papers and none of it refutes the findings in any of the Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-28924829003742402802011-06-17T14:38:07.195-04:002011-06-17T14:38:07.195-04:00Response to post by Anonymous on 6/17 1:21 PM
you...Response to post by Anonymous on 6/17 1:21 PM<br /><br />your paragraph 1 - Try to think outside the box. The cause of CFS might be a virus other than an MLV. Humans are naturally resistant to MLVs, so this type of virus is not likely to be the cause of CFS.<br /><br />paragraph 2 - Have you not seen the papers from many groups who have been completely unable to find XMRV in prostate cancer? Dusty Millernoreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-69623674068625182302011-06-17T13:57:29.105-04:002011-06-17T13:57:29.105-04:00Dusty, the serology assay in Lombardi et al. was u...Dusty, the serology assay in Lombardi et al. was unique to the SU protein of MLV viruses. It could only be identifying an immune response to an MLV virus infection, not a HERV or a mouse ERV or a virus other than an MLV. It cannot be a virus other than an MLV. <br /><br />You have no evidence that there was anything wrong with the virochip method in Urisman et al. Nothing to use to claim the Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-18636654546162222202011-06-17T13:21:46.944-04:002011-06-17T13:21:46.944-04:00Dear John, (post from 6/17 5:46 am)
Your idea o...Dear John, (post from 6/17 5:46 am)<br /><br />Your idea of using antibodies present in CFS patients' blood as a method to track down viruses that might be causing the disease is a good one in principle, but perhaps difficult in practice. The problem is that people have antibodies to all sorts of viruses in their blood, making it difficult to know which are reactive with the viruses that Dusty Millernoreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-51285990426859860282011-06-17T12:09:04.057-04:002011-06-17T12:09:04.057-04:00i did not make clear - above comment is intended f...i did not make clear - above comment is intended for D. Miller - sorry for the lack of clarity.shelleyhttp://www.facebook.com/shelleysf8noreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-16676069357114506872011-06-17T11:57:01.892-04:002011-06-17T11:57:01.892-04:00as for the your ASSumption that all of us with cfs...as for the your ASSumption that all of us with cfs want to take part in only xmrv-positive studies - you are so off base it would be laughable if it didn't cost the patients so dearly. i have had this illness since 1980, and i don't care if they find it's xmrv or vaccines that cause it - i just want someone to take seriously the fact we are suffering and are untreated -all because shelleyhttp://www.facebook.com/shelleysf8noreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-667412924699850532011-06-17T09:56:57.354-04:002011-06-17T09:56:57.354-04:00@M. Bloomer
Whoa! That's a very significant e...@M. Bloomer<br /><br />Whoa! That's a very significant epidemiological event. I hope you and your co-workers are in touch with some MDs and researchers who are following this up. That could provide a lot of very valuable data for CFS research.<br /><br />- Andy Vaughan<br /><br />While I appreciate your noticing that this report by M. Bloomer is something that should be rigorously Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-91357009484550400142011-06-17T09:51:16.615-04:002011-06-17T09:51:16.615-04:00To Anonymous of 6/17 12:46, 2:19, and 2:30 AM.
Wh...To Anonymous of 6/17 12:46, 2:19, and 2:30 AM.<br /><br />What exactly is your problem? Hiding in anonymity, barfing up the same tired story. Your Facebook proof of our criminal activity clearly states that<br /><br />"The study has NOT yet been formally announced - it will be announced once IRB approval has been received".<br /><br />Ecoclimber has ME/CFS. I have met him in person, Dusty Millernoreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-45645916180846046032011-06-17T06:46:24.668-04:002011-06-17T06:46:24.668-04:00Dusty, how is it that you don't recognise all ...Dusty, how is it that you don't recognise all the assumptions in Paprotka et al., but have repeated their conclusions. Are you not an independent thinker? How can you claim they have found the origin without proving the existence of PreXMRV-1? Without knowing which mice were used in xenografting. Without addressing the points I raised earlier. Also, they did detect XMRV env sequences in Anonymousnoreply@blogger.com