tag:blogger.com,1999:blog-1078685116296921818.post5905051580636459365..comments2023-04-26T09:15:19.142-04:00Comments on CFS Central: Rituximab, Genentech, Tony Fauci and Pertinent Pop Culture ReferencesMindy Kiteihttp://www.blogger.com/profile/12570126270241201680noreply@blogger.comBlogger30125tag:blogger.com,1999:blog-1078685116296921818.post-5288786691670361632012-01-10T06:32:20.695-05:002012-01-10T06:32:20.695-05:00I foggy forgot that we were dealing with pharmaceu...I foggy forgot that we were dealing with pharmaceuticals. <br /><br />My colleague developed a patented product with them. When it came time to clinical trials, he was dismayed that they wouldn't pay for the trials. He said it would only cost the company dollars or tens of dollars. In the end, the doctors and pharmaceutical arrived at an agreed price.<br /><br />With Rituxan, it would zachttps://www.blogger.com/profile/15189027321961226572noreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-24566035208901978372011-12-09T01:50:32.606-05:002011-12-09T01:50:32.606-05:00I personally use this medicine i think its very he...I personally use this medicine i think its very helpful for the peoples, before using this i m feeling so much tired but now i m feeling so much active & concentrate on work. <a href="www.genetech-hgh.com" rel="nofollow">Genetech</a> is one o the best resource which i used & it will be very beneficial for me.Genetechhttp://www.genetech-hgh.comnoreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-20361389344281801392011-11-30T02:55:39.212-05:002011-11-30T02:55:39.212-05:00Apple now has Rhapsody as an app, which is a great...Apple now has Rhapsody as an app, which is a great start, but it is currently hampered by the inability to store locally on your iPod, and has a dismal 64kbps bit rate. If this changes, then it will somewhat negate this advantage for the Zune, but the 10 songs per month will still be a big plus in Zune Pass' favor.<br /><a href="http://www.genetech-hgh.com" rel="nofollow">Buy HGH</a>Roller blindshttps://www.blogger.com/profile/02535746259634880359noreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-87571740166652263502011-11-07T09:46:16.894-05:002011-11-07T09:46:16.894-05:00Crikey mikey, it scares me to think what rituximab...Crikey mikey, it scares me to think what rituximab would do to my poor little personage. You know, I have recurrent viruses and knocking out my b cells would, I think probably kill me. That isn't really what I would call a cure.<br /><br />As for the artistic quest of your friends Mindy, I remember the days when I wondered about those questions. But ME is a thief which robs you of your energyboolyboolyhttps://www.blogger.com/profile/08991177380518099295noreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-48903073886509756092011-11-03T13:45:46.544-04:002011-11-03T13:45:46.544-04:00Mindy, I dare you to use the snorefest remark at t...Mindy, I dare you to use the snorefest remark at the next CFSAC next week. We must do all we can to wake them up and change what goes on at that wasteful meeting.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-85396972329228637812011-11-03T02:13:08.134-04:002011-11-03T02:13:08.134-04:00Do you have e-mail addresses and office addresses ...Do you have e-mail addresses and office addresses for Fauci? If we all e-mailed him about getting a drug trial for rituximab would that help?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-2558839657346496872011-11-02T01:41:38.736-04:002011-11-02T01:41:38.736-04:00Is this the supposed to be a consolation prize?Is this the supposed to be a consolation prize?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-31885549779275106442011-11-01T08:30:07.005-04:002011-11-01T08:30:07.005-04:00Dr Peterson does not say he has a trial going and ...Dr Peterson does not say he has a trial going and is now talking about HGRVs being involved in ME. The same viruses found in Lombardi and Lo et al.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-38318052864301351732011-10-30T12:43:44.000-04:002011-10-30T12:43:44.000-04:00I just watched a video of a great presentation tha...I just watched a video of a great presentation that Dr Peterson gave in Sweden earlier this month. He said that he is working with Roche to get a clinical trial going for rituximab ( http://vimeo.com/30567445 at 11:20.) I think Genentech's quote about having no current plans to do a trial on rituximab in ME/CFS may just be standard boilerplate and doesn't reflect the conversations going Ramblerhttps://www.blogger.com/profile/04571397449936148937noreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-2187956518553528312011-10-29T21:08:22.160-04:002011-10-29T21:08:22.160-04:00There is no money in it for them because patients ...There is no money in it for them because patients have a life long infection caused by HGRVs, which will need treatment with drugs like ARVs.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-58575561574379157142011-10-29T17:29:45.822-04:002011-10-29T17:29:45.822-04:00As other people have pointed out, the reason that ...As other people have pointed out, the reason that Genentech are not interested in trialling rituximab for ME is because they will not recoup their investment since the patent is soon to expire. Apparently, rituximab has also been trialled for MS – with favourable results. However, the research was abandoned – for the same reason, no money in it for the drug company. The pharmaceutical industry Janet Comerfordnoreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-52304035617307560552011-10-29T17:18:17.862-04:002011-10-29T17:18:17.862-04:00The patent for Rituximab is running out soon – tha...The patent for Rituximab is running out soon – that's why they are not interested.Tony Machhttps://www.blogger.com/profile/14823430729798784689noreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-56563829380185248192011-10-29T16:04:45.035-04:002011-10-29T16:04:45.035-04:00Fauci is and has always been the problem. He's...Fauci is and has always been the problem. He's the gatekeeper at the top for the NIH division my brain is too dead to remember.<br /><br />Please correct me if I'm wrong, but many biotech meds, such as monoclonal antibodies are hard to duplicate, i.e, make generics from. <br /><br />Genentech's lack of interest is stunning. Thanks, Mindy for a good blog<br /><br />michaelAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-307081499322439842011-10-29T10:27:50.941-04:002011-10-29T10:27:50.941-04:00I think it may be difficult to get Genentech to do...I think it may be difficult to get Genentech to do a trial for the reason Justin mentioned- they aren't going to start a trial when their patent is expiring in 2015. It is really expensive to do large studies. But, it is important to note that the vast majority of the 1100+ rituximab studies are not being run by Roche/Genentech. I know at least some researchers in the US are looking into Ramblerhttps://www.blogger.com/profile/04571397449936148937noreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-87797223432752194552011-10-29T09:31:30.394-04:002011-10-29T09:31:30.394-04:00Hmm .. the gov't site says ..
NCI: [Rituxima...Hmm .. the gov't site says .. <br /><br />NCI: [Rituximab is a] recombinant chimeric murine/human antibody ..<br /><br />I wonder if its partly murine nature suggests another mode of action within us. I suppose they could trial a non-murine equivalent antibody to exclude that possibility.zachttps://www.blogger.com/profile/15189027321961226572noreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-74783640456526936032011-10-29T08:40:44.087-04:002011-10-29T08:40:44.087-04:00Thanks for being a voice of action in our communit...Thanks for being a voice of action in our community, Mindy.<br /><br />Like Kati says, Clinicaltrials.gov lists over 1100 studies with rituximab. I see 411 of those studies are "recruiting" or "not yet recruiting".<br /><br />Perhaps we should be asking the drug companies what it would take to get onto clinical trials with rituximab. I believe they may have interest, just nozachttps://www.blogger.com/profile/15189027321961226572noreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-4065978376144425432011-10-29T07:17:37.388-04:002011-10-29T07:17:37.388-04:00Thanks for covering this, Mindy. The story has had...Thanks for covering this, Mindy. The story has had such a big impact in Norway that Bjørn Guldvog, Deputy Director General of theNorwegian Directorate of Health made the following statement: "I think that we have not cared for people with ME to a great enough extent. I think it is correct to say that we have not established proper health care services for these people, and I regret that.&Sashanoreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-80681625751885396652011-10-29T06:43:01.284-04:002011-10-29T06:43:01.284-04:00good one. Love the snore fest part.
Markgood one. Love the snore fest part.<br /><br />MarkAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-22066757821034708242011-10-29T01:56:51.586-04:002011-10-29T01:56:51.586-04:00Found another source stating the following regardi...Found another source stating the following regarding the patent on Rituxan (Rituximab): "Roche has claimed patent protection for the drug until at least 2015 and possibly 2018 in the USA and 2013 elsewhere"<br /><br />From here: http://www.pharmatimes.com/article/11-01-06/Spectrum_plans_to_develop_biosimilar_Rituxan.aspxDavidhttps://www.blogger.com/profile/10778342601996392913noreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-68147734622307877782011-10-28T22:51:27.064-04:002011-10-28T22:51:27.064-04:00dsdmom on a forum noted that Rituxan's patent ...dsdmom on a forum noted that Rituxan's patent runs out in 2015. Sounds to me like why they wouldn't want to do a trial.<br /><br />"Looks like genentech's patent expires 2015 for Rituxan. So if it takes a couple years to get a study going then a couple years to do the study, it wouldn't make much sense for them $ wise since it'd be off patent by the time the results cameJustinhttps://www.blogger.com/profile/16661093224060056052noreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-74120373256607127622011-10-28T22:48:42.532-04:002011-10-28T22:48:42.532-04:00Thank you for the excellent post Mindy. I like yo...Thank you for the excellent post Mindy. I like your suggestions.<br /><br />You mentioned that Rituxan might get us better enough that we can be ignored. I think quite the opposite. they are doing nothing for us now and we have lots of trouble fighting back because we are so sick and bereft of resources. Some of us getting substantially better could add a lot more advocacy muscle to our causeJustinhttps://www.blogger.com/profile/16661093224060056052noreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-64737542945820493042011-10-28T22:47:04.789-04:002011-10-28T22:47:04.789-04:00Shane mentioned that the Rituximab patent rights e...Shane mentioned that the Rituximab patent rights expired soon which may not make Genentech interested in started a clinical trial on ME patients. Genentech could have said: "Our patent for Rituximab is expiring soon, but we have a new drug in the pipeline that could be just as if not more effective for your disease". however they did not say that, instead they kind of closed the door Anonymoushttps://www.blogger.com/profile/12281551619335996831noreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-9823958611723511292011-10-28T21:24:24.379-04:002011-10-28T21:24:24.379-04:00To ANON 8:53 p.m. -
Here is an article that explo...To ANON 8:53 p.m. -<br /><br />Here is an article that explorers how 2 researchers persisted in showing that Rituximab was an effective treatment for RA (hint: it wasn't easy for them): http://www.thenational.ae/news/uae-news/science/switch-off-switch-onDavidhttps://www.blogger.com/profile/10778342601996392913noreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-62419389632114103572011-10-28T20:53:23.209-04:002011-10-28T20:53:23.209-04:00What if every American patient with ME/CFS wrote G...What if every American patient with ME/CFS wrote Genentech asking for a clinical trial. Wouldn't the sheer number and the possibility of doses show how much money they could make if it were prescribed? <br /><br />How did people with RA get the attention of the drug companies?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-1078685116296921818.post-78160869080280572922011-10-28T20:03:01.881-04:002011-10-28T20:03:01.881-04:00We need to write the Canadian and American governm...We need to write the Canadian and American governments demanding Clinical trials. We need to advertise our need for these Clinical trials to push the research forward. <br /><br />MS activists got Liberation therapy into clinical trials because they pushed for it. <br /><br />We can do the same. We need a public relations arm of ME/CFS activism to actively push for these clinical trials and not Anonymousnoreply@blogger.com