Wednesday, September 29, 2010

DR. MICHAEL SNYDERMAN'S ONE-MAN DRUG TRIAL

Dr. Michael Snyderman, an oncologist at the State University of New York at Buffalo, also has Chronic Fatigue Syndrome and chronic lymphocytic leukemia (CLL), one of the cancers that's relatively common in CFS patients.  His poster presentation at the NIH conference showed that on a trial of AZT and Isentress (raltegravir)—two HIV drugs with efficacy against XMRV in test tube studies—several inflammatory cytokines decreased.  Cytokines are proteins secreted by immune and glial cells.  For Snyderman, the drop in interleukin 8 was particularly striking.  His CLL numbers decreased as welland his CLL cells expressed XMRV. 

In an email, Snyderman wrote to CFS Central, “I believe there is excellent supporting data for treatment trials to start right now (as long as a good lab like Judy's [Mikovits] is involved). I am upset by delays when people with neurological, autoimmune and neoplastic disease are suffering. I don't know if treatment will work but my personal data validates trials. This is why I have put myself through this. I knew I was working with a center of excellence (WPI), and if there was anything important to learn, we would.  Waiting more to do these studies will not make the data stronger or more convincing. The studies can be modest at first to learn the parameters before doing a multi-million dollar study.”

Snyderman promises a longer interview with CFS Central in two weeks.  Right now, he’s snowed under finishing another poster presentation, this one for MD Anderson Cancer Hospital at the University of Texas.

15 comments:

  1. I'm very interested to hear more about Dr. Snyderman and look forward to a future interview, especially since I live close to Buffalo. Thanks for all you do, Mindy!

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  2. Wow Mindy, You and Dr. Jamie Deckoff-Jones are quite a tag team. She posted Dr. Snyderman's poster yesterday and you follow up with this fabulous news that he is both the author of the study and the patient. Thanks to both of our brave doctors who are out in front, putting themselves at risk, and willing to share their experiences with other patients. Our representation is growing more solid by the day.

    For those that haven't seen it, here's the link to the poster: http://treatingxmrv.blogspot.com/

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  3. Wow is absolutely right! Mindy, Thank You!

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  4. Thank you Mindy for your continued excellence in reporting. We need you badly.

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  5. I agree with Dr. Snyderman: "Waiting more to do these studies will not make the data stronger or more convincing." We need clinical trials now!

    Patricia Carter
    www.mecfsforums.com

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  6. Can't help it: We need you badly, we love you madly!

    Thanks, Dr. Snyderman; one more doctor converted to our cause is one more without blinders and ignorance. I cannot find one doctor in my 1.7M person city that will 'treat' a CFS patient.

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  7. wonderful news! thanks to dr snyderman for taking the risks involved in doing this study.

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  8. More astonishing news, Mindy.

    This is the Dr. Snyderman who so impressed our Patient Advocate, Chris Cairns, in his 9 September blog post, "Hire This Guy."

    What a revelation to learn that Dr. Snyderman himself is a patient of both CFS and CLL.

    Bless you, Dr. Snyderman, for your very personal devotion to pathbreaking science, prompt clinical trials of antiretrovirals, and enlightened clinical care for patients.

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  9. Great report, Mindy. I am looking forward to hearing more from Dr. Snyderman and am certainly wishing him much success.

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  10. Thank you so much Mindy. Dr. De Meirleir highlighted the effect of your presence at the Workshop. With your questions you putted some pressure on the virologists to start the clinical trials a.s.a.p.
    I'm willing to move to Nevada and become a guinea pig. Thank you for all the detailed information. You and dr. Deckhoff are priceless.

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  11. Mindy,
    When is (or was) Dr. Snyderman's poster presentation at MD Anderson Houston? I know a nursing professor there; I'd like for her to go see it if she can.

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  12. Do you know when Dr. Snyderman will be giving his poster presentation at MD Anderson Cancer Hospital? As I live in Houston, I would love
    to meet him and hear his presentation.

    Thank you so very much for your excellent reporting. You cannot imagine how much you mean to those of us suffering from this disease.

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  13. I don't know the date of the presentation at MD Anderson, but I'll try to find out.

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  14. I hear WPI and others advocating for 'centers of excellence". I wish I knew what these were.

    Also, I wonder if Snyderman incorporated some of Broderick's (ref Klimas(?)) work in his biomarkers. I guess this may come in a later interview.

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  15. I wonder if this is any good for us?

    http://www.telegraph.co.uk/science/science-news/3349596/Patients-free-from-cancer-after-immune-boost-treatment.html

    talks about NHL, ALL

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